MicroRNAs: target recognition and regulatory functions

David P Bartel

doi:10.1016/j.cell.2009.01.002

MicroRNAs: target recognition and regulatory functions

Cell. 2009 Jan 23;136(2):215-33. doi: 10.1016/j.cell.2009.01.002.

Author

David P Bartel¹

Affiliation

¹ Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dbartel@wi.mit.edu

Abstract

MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

3' Untranslated Regions / metabolism
Animals
Gene Expression Regulation*
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism*

Substances

3' Untranslated Regions
MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding