Abstract
One arm of the gut-associated immune system is represented by a vast collection of T lymphocytes which participate in the subtle interplay between innate and adaptive immune mechanisms and maintain homeostasis at the main body external surface. Mounting data are providing exciting new insight into the innate-like mechanisms which enable intestinal T cells to rapidly sense local conditions and which broaden the spectrum of their functions and regulation at this strategic location. Herein we discuss how innate-like T cell recognition by unconventional T cell subsets and expression of innate NK receptors might modulate immune T cell responses in the human normal or diseased intestine.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Immunity, Cellular
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Immunity, Innate*
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Immunity, Mucosal*
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Intestinal Mucosa / immunology
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Intestinal Mucosa / metabolism*
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Intestinal Mucosa / pathology
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Intestines / immunology*
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Mice
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NK Cell Lectin-Like Receptor Subfamily D / immunology
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NK Cell Lectin-Like Receptor Subfamily D / metabolism*
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NK Cell Lectin-Like Receptor Subfamily K / immunology
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NK Cell Lectin-Like Receptor Subfamily K / metabolism*
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Natural Killer T-Cells / immunology
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Natural Killer T-Cells / metabolism*
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Natural Killer T-Cells / pathology
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Receptors, Antigen, T-Cell, gamma-delta / metabolism
Substances
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NK Cell Lectin-Like Receptor Subfamily D
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NK Cell Lectin-Like Receptor Subfamily K
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Receptors, Antigen, T-Cell, gamma-delta