Abstract
Antitumor necrosis factor antibodies are widely used in the treatment of autoimmune diseases. We describe the occurrence of autoimmune hepatitis in a patient treated with adalimumab, a fully human IgG antibody against tumor necrosis factor, for psoriatic arthritis. The patient made a full recovery after discontinuation of adalimumab and treatment with steroids. This is the first reported case of adalimumab-induced autoimmune hepatitis.
MeSH terms
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Adalimumab
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Adult
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents / adverse effects*
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Antirheumatic Agents / therapeutic use
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Chemical and Drug Induced Liver Injury / drug therapy
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Chemical and Drug Induced Liver Injury / etiology
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Female
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Follow-Up Studies
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Glucocorticoids / therapeutic use
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Hepatitis, Autoimmune / drug therapy
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Hepatitis, Autoimmune / etiology*
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Humans
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Immunoglobulin G / immunology
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Prednisone / therapeutic use
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents
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Glucocorticoids
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Immunoglobulin G
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Adalimumab
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Prednisone