Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung

Verena Lammel; Christina Stoeckle; Barbara Padberg; Roland Zweifel; Dirk L Kienle; Walter H Reinhart; Hans-Uwe Simon

doi:10.1016/j.lungcan.2012.02.014

Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung

Lung Cancer. 2012 Jun;76(3):493-5. doi: 10.1016/j.lungcan.2012.02.014. Epub 2012 Mar 13.

Authors

Verena Lammel¹, Christina Stoeckle, Barbara Padberg, Roland Zweifel, Dirk L Kienle, Walter H Reinhart, Hans-Uwe Simon

Affiliation

¹ Department of Internal Medicine, Kantonsspital Graubünden, Chur, Switzerland.

PMID: 22420949
DOI: 10.1016/j.lungcan.2012.02.014

Abstract

In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Large Cell / complications*
Carcinoma, Large Cell / drug therapy
Carcinoma, Large Cell / metabolism*
Eosinophilia / diagnosis
Eosinophilia / etiology*
Fatal Outcome
Granulocyte Colony-Stimulating Factor / blood*
Humans
Lung Neoplasms / complications*
Lung Neoplasms / drug therapy
Lung Neoplasms / metabolism*
Male
Middle Aged

Substances

Granulocyte Colony-Stimulating Factor