Genetic "lnc"-age of noncoding RNAs to human disease

J Clin Invest. 2012 Nov;122(11):3837-40. doi: 10.1172/JCI66645. Epub 2012 Oct 24.

Abstract

The list of functions of long noncoding RNAs (lncRNAs) in human tissues is rapidly growing. To further underscore their critical role in human health, two reports in this issue of JCI associate altered expression of novel lncRNAs with the heritable syndromes HELLP and brachydactyly type E.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brachydactyly*
  • Cell Cycle / genetics*
  • Chromosomes, Human, Pair 12*
  • Chromosomes, Human, Pair 17*
  • Female
  • Gene Expression Regulation*
  • Genetic Diseases, Inborn*
  • Genetic Loci*
  • HELLP Syndrome*
  • Humans
  • Male
  • Pregnancy
  • RNA, Long Noncoding*
  • Translocation, Genetic*
  • Trophoblasts / metabolism*

Substances

  • RNA, Long Noncoding