Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia

Anirban Maitra; Steven D Leach

doi:10.1016/j.ccr.2012.11.015

Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia

Cancer Cell. 2012 Dec 11;22(6):701-3. doi: 10.1016/j.ccr.2012.11.015.

Authors

Anirban Maitra¹, Steven D Leach

Affiliation

¹ Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

In this issue of Cancer Cell, Kopp and colleagues report that pancreatic ductal cells are largely refractory to the induction of pancreatic neoplasia. Whereas a rare ductal subpopulation may still prove capable of neoplastic transformation, these findings refocus attention on acinar and other non-ductal cell types as initiators of this deadly neoplasm.

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