Abstract
Competitive inhibition assays using monoclonal antibodies reacting with defined sequence of the "a" determinant of hepatitis B surface antigen (HBsAg) indicate that the humoral response to plasma-derived and recombinant HBsAg vaccine is similar in quantitative and qualitative terms. Both vaccines evoke an antibody response to the RFHBs 1 epitope, which is known in animal experiments to be protective.
MeSH terms
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Adolescent
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Adult
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Epitopes / immunology
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Hepatitis B Antibodies / analysis
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Hepatitis B Antibodies / biosynthesis*
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Hepatitis B Surface Antigens / immunology*
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Hepatitis B Vaccines
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Humans
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Male
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Radioimmunoassay
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Recombinant Proteins / immunology
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Viral Hepatitis Vaccines / immunology*
Substances
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Epitopes
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Hepatitis B Vaccines
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Recombinant Proteins
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Viral Hepatitis Vaccines