Diverse roles of LPA signaling in the intestinal epithelium

Exp Cell Res. 2015 May 1;333(2):201-207. doi: 10.1016/j.yexcr.2014.11.013. Epub 2014 Nov 26.

Abstract

Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signaling in the intestinal tract.

Keywords: Colon cancer; Inflammation; Intestine; Lysophosphatidic acid.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cell Communication
  • Colorectal Neoplasms / metabolism
  • Humans
  • Intestinal Absorption
  • Intestinal Mucosa / metabolism*
  • Intestinal Mucosa / pathology
  • Lysophospholipids / physiology*
  • Signal Transduction

Substances

  • Lysophospholipids
  • lysophosphatidic acid