Abstract
Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Anti-Bacterial Agents / therapeutic use
-
Antibodies, Bacterial / analysis*
-
Endotoxins / blood
-
Endotoxins / immunology*
-
Female
-
Humans
-
Immunoglobulin G / analysis
-
Immunoglobulin G / immunology*
-
Immunoglobulin G / physiology
-
Lipopolysaccharides / blood
-
Lipopolysaccharides / immunology*
-
Male
-
Pneumococcal Infections / blood
-
Pneumococcal Infections / immunology
-
Pneumococcal Infections / therapy
-
Shock, Septic / blood
-
Shock, Septic / immunology*
-
Shock, Septic / therapy
-
Time Factors
Substances
-
Anti-Bacterial Agents
-
Antibodies, Bacterial
-
Endotoxins
-
Immunoglobulin G
-
Lipopolysaccharides
-
core endotoxin