Abstract
We report the purification, structure and biological properties of a peptide of novel sequence from human granulocytes that inhibits ACTH stimulated synthesis of corticosterone in rat adrenal cell suspensions. The peptide HP-4 is homologous to a previously described human granulocyte peptide HP-1 that has no anti-ACTH activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenal Glands / cytology
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Adrenal Glands / drug effects
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Adrenal Glands / metabolism
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Adrenocorticotropic Hormone / antagonists & inhibitors*
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Amino Acid Sequence
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Animals
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Cell Line
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Cricetinae
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Granulocytes / analysis*
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Growth Inhibitors / isolation & purification
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Growth Inhibitors / physiology
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Humans
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Intercellular Signaling Peptides and Proteins
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Mice
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Molecular Sequence Data
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Peptides / isolation & purification*
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Peptides / physiology
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Rats
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Structure-Activity Relationship
Substances
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Growth Inhibitors
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Intercellular Signaling Peptides and Proteins
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Peptides
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corticostatin
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Adrenocorticotropic Hormone