Abstract
A profound and long-lasting state of specific immune unresponsiveness may be induced in adult inbred mice given a single dose of protein immunogens--such as ovalbumin or hemocyanin--by the digestive route. The degree of unresponsiveness induced by intragastric exposure to ovalbumin could not be achieved by intravenous injection of deaggregated ovalbumin solutions across a wide range of doses. Unresponsiveness induced by intragastric exposure to hapten-protein conjugates is specific to the carrier protein.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Administration, Oral
-
Animals
-
Antibody Formation
-
Antigens / administration & dosage*
-
Dinitrobenzenes / administration & dosage
-
Female
-
Hemocyanins / administration & dosage
-
Immune Tolerance*
-
Injections, Intraperitoneal
-
Injections, Intravenous
-
Intubation, Gastrointestinal
-
Mice
-
Mice, Inbred C57BL
-
Mice, Inbred DBA
-
Ovalbumin / administration & dosage
-
Ovomucin / administration & dosage
Substances
-
Antigens
-
Dinitrobenzenes
-
Ovomucin
-
Ovalbumin
-
Hemocyanins