Abstract
Neurotensin is a peptide recently discovered in the human ileum and it is released into plasma after ingestion of food. Neurotensin was infused intravenously into 12 healthy volunteers at a mean dose of 2.4 pmol/kg/min, the mean rise in plasma levels being 89 +/- 8 pmol/l. An inhibition of both gastric acid and pepsin output, and also a delay in gastric emptying of oral glucose, were observed. Neurotensin may therefore have a physiological role in modulating gastric function in man.
MeSH terms
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Adult
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Animals
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Cattle
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Depression, Chemical
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Female
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Gastric Emptying* / drug effects
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Gastric Juice / metabolism*
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Gastric Mucosa / drug effects
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Hormone Antagonists
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Hormones / administration & dosage
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Humans
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Ileum / metabolism
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Infusions, Parenteral
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Male
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Neurotensin / administration & dosage
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Neurotensin / physiology*
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Pentagastrin / administration & dosage
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Pentagastrin / antagonists & inhibitors
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Pepsin A / antagonists & inhibitors
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Pepsin A / metabolism*
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Stimulation, Chemical
Substances
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Hormone Antagonists
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Hormones
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Neurotensin
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Pepsin A
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Pentagastrin