To aid in case selection for pancreatoduodencetomy and to gain information on the technical management of this operation and its complications, records of 279 patients who were treated for neoplasm or pancreatitis by this procedure between the years 1957 and 1975 were reviewed. The overall operative mortality was 12.5 per cent and was 10.7 per cent for the years 1969 throught 1974. The use of vagotomy did not prevent postoperative bleeding from the stomach, and the use of a stent did not make a statistically significant difference in morbidity or mortality. Postoperative hemorrhage is an ominous complication and is best treated conservatively until blood loss cannot be replaced. Preoperative serum bilirubin levels above 20 mg/100 ml indicate a two-stage operative procedure as does the presence of right upper quadrant sepsis. The resection of malignant disease of the duodenum and lower bile duct is followed by a high mortality and requires total pancreatectomy if a satisfactory pancreatojejunostomy cannot be constructed.