Screening for corticosteroid contact hypersensitivity

Contact Dermatitis. 1995 Sep;33(3):149-51. doi: 10.1111/j.1600-0536.1995.tb00535.x.

Abstract

To evaluate which corticosteroids are most useful for the detection of corticosteroid contact allergy in our population, 2123 patients were patch tested with a series of 6 corticosteroids, in parallel with a standard series, and other relevant investigations. 127 patients (5.98%) were allergic to one or more corticosteroids; 96 to tixocortol pivalate, 51 to hydrocortisone butyrate, 47 to budesonide, 11 to betamethasone valerate, 11 to clobetasone butyrate and 8 to clobetasol propionate. 511 patients with negative patch tests to the limited corticosteroid series were in addition tested to a further 12 corticosteroids; only 1 of these patients reacted to a corticosteroid. A combination of tixocortol pivalate and budesonide thus detected 91.3% of corticosteroid-allergic subjects. We believe that both these allergens should be included in the standard series and that there may be a case for extending this further.

MeSH terms

  • Anti-Inflammatory Agents / adverse effects*
  • Dermatitis, Allergic Contact / etiology*
  • Drug Hypersensitivity / etiology*
  • Glucocorticoids / adverse effects*
  • Humans
  • Patch Tests*
  • Steroids

Substances

  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Steroids