Molecular mimicry between Helicobacter pylori and the host

Trends Microbiol. 1997 Feb;5(2):70-3. doi: 10.1016/S0966-842X(96)10084-6.

Abstract

Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / biosynthesis
  • Autoantibodies / biosynthesis
  • Bacterial Proteins / genetics
  • Bacterial Proteins / immunology
  • Gastric Mucosa / immunology
  • Helicobacter Infections / etiology
  • Helicobacter Infections / immunology
  • Helicobacter Infections / pathology
  • Helicobacter pylori / genetics
  • Helicobacter pylori / immunology*
  • Helicobacter pylori / pathogenicity
  • Humans
  • Lewis Blood Group Antigens / immunology
  • Lipopolysaccharides / immunology
  • Mice
  • Molecular Mimicry*

Substances

  • Antibodies, Monoclonal
  • Autoantibodies
  • Bacterial Proteins
  • Lewis Blood Group Antigens
  • Lipopolysaccharides