The three most prominent advances in colonoscopic polypectomy are the submucosal injection of saline to ensure safety of polypectomy, the use of the small, or mini, snare for removal of most colon polyps, and the introduction of the argon plasma coagulator for the treatment of vascular abnormalities of the colon and the fulguration of residual adenoma at the base of sessile polyps with a noncontact technique. The role of Endoloop, endoscopic clips, and rubber band ligation for polypectomy is discussed.