Colorectal dysplasia and carcinoma in patients with ulcerative colitis and primary sclerosing cholangitis

M H Leidenius; M A Färkkilä; P Kärkkäinen; E I Taskinen; I H Kellokumpu; K A Höckerstedt

doi:10.3109/00365529708996522

Colorectal dysplasia and carcinoma in patients with ulcerative colitis and primary sclerosing cholangitis

Scand J Gastroenterol. 1997 Jul;32(7):706-11. doi: 10.3109/00365529708996522.

Authors

M H Leidenius¹, M A Färkkilä, P Kärkkäinen, E I Taskinen, I H Kellokumpu, K A Höckerstedt

Affiliation

¹ Fourth Dept. of Surgery, Helsinki University Central Hospital, Finland.

PMID: 9246712
DOI: 10.3109/00365529708996522

Abstract

Background: The aim of this study was to evaluate the role of primary sclerosing cholangitis (PSC) as a cofactor in the dysplasia-carcinoma sequence in ulcerative colitis (UC).

Methods: Forty-five patients with UC and concomitant PSC and 45 pair-matched control patients with UC only were examined for colorectal dysplasia and carcinoma.

Results: The median duration of UC was 11 years in the group with UC and PSC and 15 years in the control group. Thirteen of the 45 patients (29%) with UC and PSC had colorectal neoplasia: 4, carcinoma; 2, high-grade dysplasia; and 7, low-grade dysplasia. Four of the 45 control patients (9%) had neoplastic findings: 1, carcinoma; 1, high-grade dysplasia, and 2, low-grade dysplasia (P < 0.05).

Conclusion: The results suggest that the risk of colorectal dysplasia and carcinoma in patients with UC is increased by concomitant PSC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Case-Control Studies
Cholangitis, Sclerosing / epidemiology*
Colitis, Ulcerative / epidemiology*
Colorectal Neoplasms / epidemiology*
Female
Humans
Incidence
Male
Risk Factors
Time Factors