IL-6: insights into novel biological activities

Clin Immunol Immunopathol. 1997 Oct;85(1):16-20. doi: 10.1006/clin.1997.4420.

Abstract

IL-6 has many novel activities both within the adaptive immune system and without. It has therapeutic potential in acute inflammation, such as toxic or septic shock, and it is a potential target for cachexia, multiple myeloma, and osteoporosis. Further work on these aspects of IL-6 biology should yield new insight into the possibility of IL-6 both as a therapeutic agent and as a target for antagonists.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Bone Resorption / etiology
  • Bone Resorption / immunology
  • Cachexia / etiology
  • Cachexia / immunology
  • Cytokines / genetics
  • Cytokines / pharmacology
  • Cytokines / physiology
  • Humans
  • Interleukin-6 / genetics
  • Interleukin-6 / pharmacology
  • Interleukin-6 / physiology*
  • Neutralization Tests
  • Osteoclasts / physiology

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Interleukin-6