Abstract
IL-6 has many novel activities both within the adaptive immune system and without. It has therapeutic potential in acute inflammation, such as toxic or septic shock, and it is a potential target for cachexia, multiple myeloma, and osteoporosis. Further work on these aspects of IL-6 biology should yield new insight into the possibility of IL-6 both as a therapeutic agent and as a target for antagonists.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Bone Resorption / etiology
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Bone Resorption / immunology
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Cachexia / etiology
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Cachexia / immunology
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Cytokines / genetics
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Cytokines / pharmacology
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Cytokines / physiology
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Humans
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Interleukin-6 / genetics
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Interleukin-6 / pharmacology
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Interleukin-6 / physiology*
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Neutralization Tests
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Osteoclasts / physiology
Substances
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Anti-Inflammatory Agents
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Cytokines
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Interleukin-6