Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints

Stat Med. 1998 Dec 30;17(24):2815-34. doi: 10.1002/(sici)1097-0258(19981230)17:24<2815::aid-sim110>3.0.co;2-8.

Abstract

Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. When the studies involve time to event (survival-type) data the most appropriate statistics to use are the log hazard ratio and its variance. However, these are not always explicitly presented for each study. In this paper a number of methods of extracting estimates of these statistics in a variety of situations are presented. Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Humans
  • Meta-Analysis as Topic*
  • Proportional Hazards Models
  • Randomized Controlled Trials as Topic
  • Survival Analysis*