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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.
Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. Kudo Y, et al. Among authors: senni n. Cancer Cell. 2020 Aug 10;38(2):247-262.e11. doi: 10.1016/j.ccell.2020.05.018. Epub 2020 Jun 25. Cancer Cell. 2020. PMID: 32589943 Free PMC article.
Lkb1 suppresses amino acid-driven gluconeogenesis in the liver.
Just PA, Charawi S, Denis RGP, Savall M, Traore M, Foretz M, Bastu S, Magassa S, Senni N, Sohier P, Wursmer M, Vasseur-Cognet M, Schmitt A, Le Gall M, Leduc M, Guillonneau F, De Bandt JP, Mayeux P, Romagnolo B, Luquet S, Bossard P, Perret C. Just PA, et al. Among authors: senni n. Nat Commun. 2020 Nov 30;11(1):6127. doi: 10.1038/s41467-020-19490-6. Nat Commun. 2020. PMID: 33257663 Free PMC article.
β-catenin-activated hepatocellular carcinomas are addicted to fatty acids.
Senni N, Savall M, Cabrerizo Granados D, Alves-Guerra MC, Sartor C, Lagoutte I, Gougelet A, Terris B, Gilgenkrantz H, Perret C, Colnot S, Bossard P. Senni N, et al. Gut. 2019 Feb;68(2):322-334. doi: 10.1136/gutjnl-2017-315448. Epub 2018 Apr 12. Gut. 2019. PMID: 29650531
Author Correction: Lkb1 suppresses amino acid-driven gluconeogenesis in the liver.
Just PA, Charawi S, Denis RGP, Savall M, Traore M, Foretz M, Bastu S, Magassa S, Senni N, Sohier P, Wursmer M, Vasseur-Cognet M, Schmitt A, Le Gall M, Leduc M, Guillonneau F, De Bandt JP, Mayeux P, Romagnolo B, Luquet S, Bossard P, Perret C. Just PA, et al. Among authors: senni n. Nat Commun. 2021 Mar 17;12(1):1831. doi: 10.1038/s41467-021-22104-4. Nat Commun. 2021. PMID: 33731695 Free PMC article. No abstract available.
AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.
Abitbol S, Dahmani R, Coulouarn C, Ragazzon B, Mlecnik B, Senni N, Savall M, Bossard P, Sohier P, Drouet V, Tournier E, Dumont F, Sanson R, Calderaro J, Zucman-Rossi J, Vasseur-Cognet M, Just PA, Terris B, Perret C, Gilgenkrantz H. Abitbol S, et al. Among authors: senni n. J Hepatol. 2018 Jun;68(6):1203-1213. doi: 10.1016/j.jhep.2017.12.018. Epub 2018 Mar 7. J Hepatol. 2018. PMID: 29525529
Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.
Gougelet A, Sartor C, Senni N, Calderaro J, Fartoux L, Lequoy M, Wendum D, Talbot JN, Prignon A, Chalaye J, Imbeaud S, Zucman-Rossi J, Tordjmann T, Godard C, Bossard P, Rosmorduc O, Amaddeo G, Colnot S. Gougelet A, et al. Among authors: senni n. Gastroenterology. 2019 Sep;157(3):807-822. doi: 10.1053/j.gastro.2019.05.069. Epub 2019 Jun 10. Gastroenterology. 2019. PMID: 31194980