It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

One long-standing approach for improving transdermal drug delivery uses penetration
enhancers (also called sorption promoters or accelerants) which penetrate into skin to …

The early eighties saw the introduction of liposomes as skin drug delivery systems, initially
promoted primarily for localised effects with minimal systemic delivery. Subsequently, a …

Abstract Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener,
produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor …

Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in
aqueous solutions at pH< 6.5. It has been widely used for developing drug delivery systems …

This paper reports interactions and possible incompatibilities in solid dispersions of
hydrophobic drugs with hydrophilic carriers, with solubility parameters employed as a …

A series of terpenes has been assessed as skin penetration enhancers towards the model
polar penetrant 5-fluorouracil (5-FU). Cyclic terpenes were selected from the chemical …

Aberrant activation of β-catenin promotes cell proliferation and initiates colorectal
tumorigenesis,. However, the expansion of tumours and the inadequacy of their local …

Regeneration of CNS myelin involves differentiation of oligodendrocytes from
oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite …

The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …