Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

NA Kennedy, GA Heap, HD Green… - The lancet …, 2019 - thelancet.com
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

Natural history of Crohn's disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection rates

AV Ramadas, S Gunesh, GAO Thomas, GT Williams… - Gut, 2010 - gut.bmj.com
Introduction Benefits of immunosuppressive therapy in Crohn's disease have been
demonstrated in controlled trials; however, it is unclear whether these drugs alter the longer …

[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease

A Sazonovs, NA Kennedy, L Moutsianas, GA Heap… - Gastroenterology, 2020 - Elsevier
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …

Narrow band imaging optical diagnosis of small colorectal polyps in routine clinical practice: the Detect Inspect Characterise Resect and Discard 2 (DISCARD 2) study

CJ Rees, PT Rajasekhar, A Wilson, H Close, MD Rutter… - Gut, 2017 - gut.bmj.com
Background Accurate optical characterisation and removal of small adenomas (< 10 mm) at
colonoscopy would allow hyperplastic polyps to be left in situ and surveillance intervals to …

Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial

WS Ngu, R Bevan, ZP Tsiamoulos, P Bassett, Z Hoare… - Gut, 2019 - gut.bmj.com
Objective Low adenoma detection rates (ADR) are linked to increased postcolonoscopy
colorectal cancer rates and reduced cancer survival. Devices to enhance mucosal …

I-CARE, a European prospective cohort study assessing safety and effectiveness of biologics in inflammatory bowel disease

L Peyrin-Biroulet, JF Rahier, J Kirchgesner… - Clinical …, 2023 - Elsevier
Background and Aims There is a need to evaluate the benefit-risk ratio of current therapies
in inflammatory bowel disease (IBD) patients to provide the best quality of care. The primary …

[PDF][PDF] Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial

D Gunn, R Topan, R Fried, I Holloway… - Efficacy and …, 2023 - qmro.qmul.ac.uk
David Gunn, 1, 2 Rabia Topan, 3 Ron Fried, 4 Ivana Holloway, 5 Richard Brindle, 5
Suzanne Hartley, 5 Lorna Barnard, 5 Maura Corsetti, 2 S Mark Scott, 3 Adam Farmer, 6 …

[PDF][PDF] Should we Investigate Gastroenterology Patients for Pancreatic Exocrine Insufficiency? A Dual Centre UK Study.

JA Campbell, DS Sanders, KA Francis… - … of Gastrointestinal & …, 2016 - academia.edu
ABSTRACT Background & Aims: Pancreatic exocrine insufficiency may be under recognised
in gastroenterological practice. We aimed to identify the prevalence of pancreatic …

Enhanced Neoplasia Detection in Chronic ulcerative colitis: results of the ENDCaP-C Diagnostic accuracy study

ENDCaP-C Collaborative Group, A Awasthi, J Barbour… - medRxiv, 2022 - medrxiv.org
Background Chronic ulcerative colitis is an inflammatory condition associated with a pro-
neoplastic drive, predisposing to colorectal cancer. Repeated colonoscopy is undertaken to …

P355 Immersion blocks in early gastroscopy training improve technical skill acquisition in novice trainees–regional multicentre training academy results

F Brown, R Bevan, C Parker, A Ramadas, R Sinha… - 2023 - gut.bmj.com
Introduction UK endoscopy training faces challenges from increasing service pressure and
changes to specialty training curricula. 1 Endoscopy training academies are a potential …