Background Faecal incontinence is a particularly embarrassing and distressing condition
with significant medical, social and economic implications. Anal sphincter exercises (pelvic …

Background People with central neurological disease or injury have a much higher risk of
both faecal incontinence and constipation than the general population. There is often a fine …

Background Faecal incontinence is a complex and distressing condition with significant
medical and social implications. Injection of perianal bulking agents has been used to treat …

The Notch gene family encodes large transmembrane receptors that are components of an
evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 …

The Notch signaling pathway is an evolutionarily conserved intercellular signaling
mechanism essential for embryonic development in mammals. Mutations in the human …

In aging men, the prostate gland becomes hyperproliferative and displays a propensity
toward carcinoma. Although this hyperproliferative process has been proposed to represent …

Background Anterior structural damage to the anal sphincter occurs in up to a third of
women at first vaginal delivery, and of these a third have new bowel symptoms. The …

The Notch signaling pathway is a conserved intercellular signaling mechanism that is
essential for proper embryonic development in numerous metazoan organisms. We have …

BACKGROUND & AIMS:: Behavioral treatment (biofeedback) has been reported to improve
fecal incontinence but has not been compared with standard care. METHODS:: A total of 171 …

N-of-1 Trial of a Statin, Placebo, or No Treatment Patients who had discontinued statins
because of side effects received four bottles of a statin, four bottles of placebo, and four …