Various studies in cell lines have previously demonstrated that sphingosine kinase 1 (SK1)
and extracellular signal-regulated kinase 1/2 (ERK-1/2) interact in an estrogen receptor (ER) …

There is a need for transplantable murine models of ovarian high-grade serous carcinoma
(HGSC) with regard to mutations in the human disease to assist investigations of the …

Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on …

Background: Recent evidence has implicated the MAP kinase (MAPK) pathway with the
development of castrate-resistant prostate cancer (CRPC). We have previously reported …

The cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the
early stages of tumorigenesis. During malignant progression, cancer cells can switch their …

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however,
little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines …

Background Several well-established tumour prognostic factors are used to guide the
clinical management of patients with breast cancer. Lymphovascular invasion and …

Background Lymphovascular invasion (LBVI) including lymphatic (LVI) and blood (BVI)
vessel invasion is a critical step in cancer metastasis. In breast cancer, the optimal detection …

Background: We previously reported that sphingosine 1-phosphate receptor 4 (S1P 4) is
expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor …

Background Tumour-infiltrating CD8+ cytotoxic T cells confer favourable prognosis in
colorectal cancer. The added prognostic value of other infiltrating immune cells is unclear …