Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer
chemotherapies. The mechanisms of MDR and the approaches to test MDR have been …

Gastric cancers, with gastric adenocarcinoma (GAC) as the most common histological type,
impose a considerable global health burden. Although the screening strategies for early …

Following dramatic success in many types of advanced solid tumors, interest in
immunotherapy for the treatment of colorectal cancer (CRC) is increasingly growing. Given …

Abstract microRNAs are endogenous small noncoding RNAs that regulate gene expression
negatively at posttranscriptional level. This latest addition to the complex gene regulatory …

Background MicroRNAs (miRNAs) have been implicated in cancer initiation and
progression via their ability to affect expression of genes and proteins that regulate cell …

Cancer is one of the major non-communicable diseases posing a threat to world health.
Unfortunately, improvements in socioeconomic conditions are usually associated with …

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and
function of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased …

Background MicroRNAs (miRNAs), some of which function as oncogenes or tumor
suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell …

Aims Several microarray studies have reported microRNA (miRNA) expression signatures
that classify cancer patients into different prognostic groups. No study has evaluated the …

Traditional research modes aim to find cancer-specific single therapeutic target. Recently,
emerging evidence suggested that some micro-RNAs (miRNA) can function as oncogenes …