[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC

D Pfister, NG Núñez, R Pinyol, O Govaere, M Pinter… - Nature, 2021 - nature.com
Hepatocellular carcinoma (HCC) can have viral or non-viral causes,,,–. Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved …

miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression

G Hanin, N Yayon, Y Tzur, R Haviv, ER Bennett, S Udi… - Gut, 2018 - gut.bmj.com
Objective Both non-alcoholic fatty liver disease (NAFLD) and the multitarget complexity of
microRNA (miR) suppression have recently raised much interest, but the in vivo impact and …

Gut microbiome and autism spectrum disorder

E Kotsiliti - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Maralixibat is an apical sodium-dependent bile acid transport (ASBT) inhibitor that blocks
enterohepatic recirculation of bile acids and could prolong transplant-free survival in …

Lactylation and HCC progression

E Kotsiliti - Nature Reviews Gastroenterology & Hepatology, 2023 - nature.com
Despite enhanced glycolysis being a key process in cancer biology, the effects of lactylation
are not well known. A new study published in Nature Metabolism shed light on the lactylome …

Understanding HCC sex disparities

E Kotsiliti - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Hepatocellular carcinoma (HCC) has higher incidence rates in men than in women. A new
study published in Gut has demonstrated that CYP39A1, a liver-specific autosomal gene …

Structural studies of human insulin cocrystallized with phenol or resorcinol via powder diffraction

F Karavassili, AE Giannopoulou, E Kotsiliti… - … Section D: Biological …, 2012 - scripts.iucr.org
The effects of the ligands phenol and resorcinol on the crystallization of human insulin have
been investigated as a function of pH. Powder diffraction data were used to characterize …

Phage therapy suppresses gut inflammation in IBD

E Kotsiliti - Nature Biotechnology, 2022 - nature.com
The gut microbiota is known to contribute to the pathology of inflammatory bowel diseases
(IBD), including Crohn's disease and ulcerative colitis. But treatments that tackle the entire …

Origin of CAFs in colorectal cancer

E Kotsiliti - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
A genome-wide association study (GWAS) identified genetic variants associated with
alcohol-related hepatocellular carcinoma (HCC). In a discovery cohort of 2,107 unrelated …

CIDEB variants protect against liver disease

E Kotsiliti - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Deep microbiome analysis from four geographically distinct inflammatory bowel disease
(IBD) cohorts (n= 537) revealed that Klebsiella pneumoniae (Kp) was strongly associated …

De novo protein design with a language model

E Kotsiliti - Nature Biotechnology, 2022 - nature.com
Artificial intelligence models of natural language are becoming ever more adept at
processing and 'understanding'language, and are widely used in applications such as …