[HTML][HTML] Hepatitis C vaccine: 10 good reasons for continuing

P Roingeard, E Beaumont - Hepatology, 2020 - journals.lww.com
Conclusions Mass spectrometric analysis identified serine 335 in the SDS1 region of mNrf2
as the major phosphorylation site for modulation of Nrf2 ubiquitylation by P‐JNK. This study …

[HTML][HTML] IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

K Tartour, R Appourchaux, J Gaillard, XN Nguyen… - Retrovirology, 2014 - Springer
Background Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a
family of highly related antiviral factors that have been shown to interfere with a large …

[PDF][PDF] IL‐34 and macrophage colony‐stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen …

L Preisser, C Miot, H Le Guillou‐Guillemette… - …, 2014 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is characterized by progressive hepatic fibrosis, a
process dependent on monocyte recruitment and accumulation into the liver. The mediators …

[HTML][HTML] Current hepatitis C vaccine candidates based on the induction of neutralizing antibodies

E Gomez-Escobar, P Roingeard, E Beaumont - Viruses, 2023 - mdpi.com
The introduction of direct-acting antivirals (DAAs) has revolutionized hepatitis C treatment.
Short courses of treatment with these drugs are highly beneficial to patients, eliminating …

[HTML][HTML] The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles

A Boyer, A Dumans, E Beaumont, L Etienne… - Journal of Biological …, 2014 - ASBMB
In patients chronically infected with hepatitis C virus and in the HCV cell culture system
(HCVcc), it is known that highly infectious virus particles have low to very low buoyant …

[HTML][HTML] Viral load affects the immune response to HBV in mice with humanized immune system and liver

M Dusséaux, G Masse-Ranson, S Darche, J Ahodantin… - Gastroenterology, 2017 - Elsevier
Background & Aims Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the
immune response against the virus and how it affects disease progression are unclear …

[HTML][HTML] Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

P Ferraris, E Beaumont, R Uzbekov, D Brand… - Cellular and Molecular …, 2013 - Springer
Like most positive-strand RNA viruses, hepatitis C virus (HCV) forms a membrane-
associated replication complex consisting of replicating RNA, viral and host proteins …

Ultrastructural organisation of HCV from the bloodstream of infected patients revealed by electron microscopy after specific immunocapture

E Piver, A Boyer, J Gaillard, A Bull, E Beaumont… - Gut, 2017 - gut.bmj.com
Objective HCV particles are associated with very low-density lipoprotein components in
chronically infected patients. These hybrid particles, or 'lipo-viro particles'(LVPs), are rich in …

IL-26 is overexpressed in chronically HCV-infected patients and enhances TRAIL-mediated cytotoxicity and interferon production by human NK cells

C Miot, E Beaumont, D Duluc, H Le Guillou-Guillemette… - Gut, 2015 - gut.bmj.com
Objective Interleukin-26 (IL-26) is a member of the IL-10 cytokine family, first discovered
based on its peculiar expression by virus-transformed T cells. IL-26 is overexpressed in …

HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores

B Monel, E Beaumont, D Vendrame… - Journal of …, 2012 - Am Soc Microbiol
Direct cell-to-cell transmission of human immunodeficiency virus (HIV) is a more potent and
efficient means of virus propagation than infection by cell-free virus particles. The aim of this …