A numerically important group of patients with functional gastrointestinal disorders have
chronic symptoms that can be attributed to the gastroduodenal region. Based on the …

Traditionally, irritable bowel syndrome has been considered to be a disorder with no known
underlying structural or biochemical explanation, but this concept is likely to be outdated. In …

This literature review and the recommendations therein were prepared for the American
Gastroenterological Association Clinical Practice and Practice Economics Committee …

Background & Aims: We set out to test the hypothesis that irritable bowel syndrome (IBS) is
characterized by an augmented cellular immune response with enhanced production of …

There is increasing interest in the potential contribution of the gut microbiome to autism
spectrum disorder (ASD). However, previous studies have been underpowered and have …

Background Dysfunction of the gut microbiota is frequently reported as a manifestation of
chronic diseases, and therefore presents as a modifiable risk factor in their development …

Background The treatment of patients with functional dyspepsia remains unsatisfactory. We
assessed the efficacy of itopride, a dopamine D2 antagonist with acetylcholinesterase …

Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders.
Functional dyspepsia comprises three subtypes with presumed different pathophysiology …

BACKGROUND & AIMS: The transient receptor potential (TRP) channel family includes
transducers of mechanical and chemical stimuli for visceral sensory neurons. TRP ankyrin 1 …

Psychological disorders are highly prevalent in patients with inflammatory bowel disease
(IBD). Anxiety and depression are known to independently affect quality of life and may …