There are several conditions associated with dysfunction of the lower urinary tract or which
result in a reduction in the ability to engage in satisfactory sexual function and result in …

Objective Integration of nutritional, microbial and inflammatory events along the gut-brain
axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate …

Purpose: Idiopathic detrusor instability (IDI) is a common cause of lower urinary tract storage
symptoms, such as urgency, frequency and urge incontinence. We have investigated the in …

Key points Voltage‐gated sodium channels play a fundamental role in determining neuronal
excitability. Specifically, voltage‐gated sodium channel subtype NaV1. 7 is required for …

Dysmenorrhea is a common chronic pelvic pain syndrome affecting women of childbearing
potential. Family studies suggest that genetic background influences the severity of …

The development of G protein-biased agonists for the μ-opioid receptor (MOR) offers a clear
drug discovery rationale for improved analgesia and reduced side-effects of opiate …

The effects of adenosine triphosphate (ATP), adenosine diphosphate (ADP), α, β‐methylene‐
ATP (α, β‐MeATP) and 2‐methylthio‐ATP (2‐MeSATP) on longitudinally orientated smooth …

The bladder receives an extensive nerve supply that is predominantly cholinergic, but
several putative transmitters are present, some of which are colocalized. Previous studies …

Purpose: To investigate whether the pig is a suitable model for studies of lower urinary tract
function and dysfunction, we sought to determine the morphology of the female pig bladder …

A series of 4-substituted pyrimido [4, 5-d] azepines that are potent, selective 5-HT2C
receptor partial agonists is described. A rational medicinal chemistry design strategy to …