A microbial signature for Crohn's disease
Objective A decade of microbiome studies has linked IBD to an alteration in the gut microbial
community of genetically predisposed subjects. However, existing profiles of gut microbiome …
community of genetically predisposed subjects. However, existing profiles of gut microbiome …
[HTML][HTML] Advances in CAR-T cell genetic engineering strategies to overcome hurdles in solid tumors treatment
AE Andrea, A Chiron, S Mallah, S Bessoles… - Frontiers in …, 2022 - frontiersin.org
During this last decade, adoptive transfer of T lymphocytes genetically modified to express
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …
[HTML][HTML] CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease
G Sarrabayrouse, C Bossard, JM Chauvin, A Jarry… - PLoS …, 2014 - journals.plos.org
How the microbiota affects health and disease is a crucial question. In mice, gut Clostridium
bacteria are potent inducers of colonic interleukin (IL)-10-producing Foxp3 regulatory T cells …
bacteria are potent inducers of colonic interleukin (IL)-10-producing Foxp3 regulatory T cells …
[HTML][HTML] Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction
J Alameddine, E Godefroy, L Papargyris… - Frontiers in …, 2019 - frontiersin.org
The human colonic mucosa contains regulatory type 1-like (Tr1-like, ie, IL-10-secreting and
Foxp3-negative) T cells specific for the gut Clostridium Faecalibacterium prausnitzii (F …
Foxp3-negative) T cells specific for the gut Clostridium Faecalibacterium prausnitzii (F …
Regulatory properties of statins and rho gtpases prenylation inhibitiors to stimulate melanoma immunogenicity and promote anti‐melanoma immune response
G Sarrabayrouse, C Pich, I Teiti… - … journal of cancer, 2017 - Wiley Online Library
Melanoma is a highly lethal cutaneous tumor, killing affected patients through development
of multiple poorly immunogenic metastases. Suboptimal activation of immune system by …
of multiple poorly immunogenic metastases. Suboptimal activation of immune system by …
[HTML][HTML] Alteration of the serum microbiome composition in cirrhotic patients with ascites
The progression of cirrhosis is associated with alterations in the composition of the gut
microbiome. To assess microbial translocation, we compared the serum microbial …
microbiome. To assess microbial translocation, we compared the serum microbial …
[HTML][HTML] A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis
M Lleal, G Sarrabayrouse, J Willamil, A Santiago… - …, 2019 - thelancet.com
Background Faecal microbiota transplantation (FMT) is a novel potential therapy for
inflammatory bowel diseases, but it is poorly characterised. Methods We evaluated the …
inflammatory bowel diseases, but it is poorly characterised. Methods We evaluated the …
Spheroplexes: Hybrid PLGA-cationic lipid nanoparticles, for in vitro and oral delivery of siRNA
DC Arruda, AM Lachagès, H Demory, G Escriou… - Journal of Controlled …, 2022 - Elsevier
Vectorized small interfering RNAs (siRNAs) are widely used to induce gene silencing.
Among the delivery systems used, lipid-based particles are the most effective. Our objective …
Among the delivery systems used, lipid-based particles are the most effective. Our objective …
[HTML][HTML] Melanoma-expressed CD70 is involved in invasion and metastasis
C Pich, G Sarrabayrouse, I Teiti, B Mariamé… - British journal of …, 2016 - nature.com
Background: CD70 is a costimulatory molecule of the tumour necrosis factor family
expressed in activated immune cells and some solid tumours. In lymphocytes CD70 triggers …
expressed in activated immune cells and some solid tumours. In lymphocytes CD70 triggers …
[HTML][HTML] Microbiota-specific CD4CD8αα Tregs: role in intestinal immune homeostasis and implications for IBD
G Sarrabayrouse, J Alameddine, F Altare… - Frontiers in …, 2015 - frontiersin.org
In studies in murine models, active suppression by IL-10-secreting Foxp3 regulatory T cells
(Tregs) has emerged as an essential mechanism in colon homeostasis. However, the role of …
(Tregs) has emerged as an essential mechanism in colon homeostasis. However, the role of …