Ursodeoxycholic acid (UCDA) is increasingly used for the treatment of cholestatic liver
diseases. Experimental evidence suggests three major mechanisms of action:(1) protection …

ULRICH BEUERS, 1 JAMES L. BOYER, 2 AND GUSTAV PAUMGARTNER1 The dihydroxy
bile acid, ursodeoxycholic acid (UDCA), is increasingly used for the treatment of chronic …

Ursodeoxycholic acid (UDCA) is widely used for the treatment of a variety of chronic
cholestatic liver diseases. At present, it is the only drug approved by the United States Food …

We treated nine patients with functioning gallbladders containing one to three symptomatic
radiolucent stones not larger than 25 mm in diameter, as well as five patients with stones in …

The efficacy and safety of ursodeoxycholic acid for the treatment of primary sclerosing
cholangitis were evaluated in a prospective, randomized, double‐blind, placebo‐controlled …

To substantiate the early results of extracorporeal shock-wave fragmentation of gallstones,
we used this nonsurgical procedure to treat 175 patients with radiolucent gallbladder calculi …

Ursodeoxycholic acid (UDCA) exerts anticholestatic effects by undefined mechanisms.
Previous work suggested that UDCA stimulates biliary exocytosis via Ca++-and protein …

Background: Epidemiological and animal studies have suggested that the secondary bile
acid deoxycholic acid is cocarcinogenic in colorectal cancer, but this hypothesis was not …

The identification of the key regulators of bile acid (BA) synthesis and transport within the
enterohepatic circulation has revealed potential targets for pharmacological therapies of …

The alterations of hepatobiliary transport that occur in cholestasis can be divided into
primary defects, such as mutations of transporter genes or acquired dysfunctions of transport …