Genetics of IL28B and HCV—response to infection and treatment

CN Hayes, M Imamura, H Aikata… - Nature reviews …, 2012 - nature.com
The IL28B locus attracted the attention of HCV researchers after a series of genome-wide
association studies independently identified a strong association between common IL28B …

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

A Fujimoto, M Furuta, Y Totoki, T Tsunoda, M Kato… - Nature …, 2016 - nature.com
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole …

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular …

M Kudo, K Ueshima, M Ikeda, T Torimura, N Tanabe… - Gut, 2020 - gut.bmj.com
Objective This trial compared the efficacy and safety of transarterial chemoembolisation
(TACE) plus sorafenib with TACE alone using a newly established TACE-specific endpoint …

[HTML][HTML] Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma

K Uka, H Aikata, S Takaki, H Shirakawa… - World journal of …, 2007 - ncbi.nlm.nih.gov
AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic
metastases from primary hepatocellular carcinoma (HCC), and describe the treatment …

[HTML][HTML] Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

CP Wardell, M Fujita, T Yamada, M Simbolo… - Journal of …, 2018 - Elsevier
Background & Aims Biliary tract cancers (BTCs) are clinically and pathologically
heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer …

Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma …

M Kudo, K Ueshima, O Yokosuka… - The lancet …, 2018 - thelancet.com
Background Hepatic arterial infusion chemotherapy plus sorafenib in phase 2 trials has
shown favourable tumour control and a manageable safety profile in patients with advanced …

[HTML][HTML] Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

A Fujimoto, M Furuta, Y Shiraishi, K Gotoh… - Nature …, 2015 - nature.com
Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show
varying degrees of biliary epithelial differentiation, which can be defined as liver cancer …

[HTML][HTML] HCV-induced epigenetic changes associated with liver cancer risk persist after sustained virologic response

N Hamdane, F Jühling, E Crouchet, H El Saghire… - Gastroenterology, 2019 - Elsevier
Background & Aims Chronic hepatitis C virus (HCV) infection is an important risk factor for
hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is …

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

N Fujiwara, N Kubota, E Crouchet, B Koneru… - Science translational …, 2022 - science.org
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with
nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from …

Telomere reduction in human liver tissues with age and chronic inflammation

H Aikata, H Takaishi, Y Kawakami, S Takahashi… - Experimental cell …, 2000 - Elsevier
Telomere shortening in human liver with aging and chronic inflammation was examined by
hybridization protection assay using telomere and Alu probes. The reduction rate of …