During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

The tumor microenvironment plays a critical role in cancer development, progression, and
control. The molecular and cellular nature of the tumor immune microenvironment influences …

Although metastasis is the leading cause of cancer-related death, it is not clear why some
patients with localized cancer develop metastatic disease after complete resection of their …

In order to metastasize, cancer cells need to acquire a motile phenotype. Previously,
development of this phenotype was thought to rely on the acquisition of selected, random …

Objective The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical
outcome in carcinomas, including hepatocellular carcinoma (HCC). However, the role of …

Macrophages are ubiquitous cells physiologically involved in a variety of processes
including pathogen destruction, inflammation, tissue repair and remodeling. They have a …

Objective Hepatocellular carcinoma (HCC) is a heterogeneous disease with poor prognosis
and limited methods for predicting patient survival. The nature of the immune cells that …

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is an aggressive malignancy with
few treatment options. As the status of the tumour immune microenvironment can affect …

GCN4 encodes a transcriptional activator of amino acid-biosynthetic genes in
Saccharomyces cerevisiae that is regulated at the translational level by upstream open …

T-cell infiltration is known to impact tumor growth and is associated with cancer patient
survival. However, the molecular cues that favor T-cell infiltration remain largely undefined …