User profiles for "author:Karthik Devarajan"

Karthik Devarajan

Associate Professor, Fox Chase Cancer Center, Temple University Health System
Verified email at fccc.edu
Cited by 6233

[HTML][HTML] Nonnegative matrix factorization: an analytical and interpretive tool in computational biology

K Devarajan - PLoS computational biology, 2008 - journals.plos.org
In the last decade, advances in high-throughput technologies such as DNA microarrays
have made it possible to simultaneously measure the expression levels of tens of thousands …

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

T Anastassiadis, SW Deacon, K Devarajan, H Ma… - Nature …, 2011 - nature.com
Small-molecule protein kinase inhibitors are widely used to elucidate cellular signaling
pathways and are promising therapeutic agents. Owing to evolutionary conservation of the …

[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …

Improved operative efficiency of free fibula flap mandible reconstruction with patient‐specific, computer‐guided preoperative planning

JM Toto, EI Chang, R Agag, K Devarajan… - Head & …, 2015 - Wiley Online Library
Background Free fibula osteocutaneous flaps are the primary option for reconstruction after
segmental mandibulectomies. This study evaluates the impact of CT‐guided preoperative …

A mouse model recapitulating molecular features of human mesothelioma

DA Altomare, CA Vaslet, KL Skele, A De Rienzo… - Cancer research, 2005 - AACR
Malignant mesothelioma has been linked to asbestos exposure and generally has a poor
prognosis because it is often diagnosed in advanced stages and is refractory to …

Synthetic lethal screen of an EGFR-centered network to improve targeted therapies

I Astsaturov, V Ratushny, A Sukhanova… - Science …, 2010 - science.org
Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer
therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes …

[HTML][HTML] Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma

P Ghatalia, J Gordetsky, F Kuo, E Dulaimi… - … for ImmunoTherapy of …, 2019 - Springer
Background The tumor immune microenvironment has become the focus of research in
clear cell renal cell carcinoma (ccRCC) due to its important role in immune surveillance post …

[HTML][HTML] Specificity profiling of Pak kinases allows identification of novel phosphorylation sites

UEE Rennefahrt, SW Deacon, SA Parker… - Journal of Biological …, 2007 - ASBMB
The p21-activated kinases (Paks) serve as effectors of the Rho family GTPases Rac and
Cdc42. The six human Paks are divided into two groups based on sequence similarity …

The codon 72 polymorphism of p53 regulates interaction with NF-κB and transactivation of genes involved in immunity and inflammation

AK Frank, I Julia, J Leu, Y Zhou… - … and cellular biology, 2011 - Am Soc Microbiol
A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either
proline (P72) or arginine (R72). Several groups have reported that in cultured cells, this …

Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast–driven nutritional support and immunosuppression

R Francescone, D Barbosa Vendramini-Costa… - Cancer discovery, 2021 - AACR
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks
effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using …