[HTML][HTML] L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis
Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC),
results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies …
results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies …
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications
DM Hardbower, M Asim, PB Luis… - Proceedings of the …, 2017 - National Acad Sciences
Macrophage activation is a critical step in host responses during bacterial infections.
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …
[HTML][HTML] EGFR regulates macrophage activation and function in bacterial infection
DM Hardbower, K Singh, M Asim… - The Journal of …, 2016 - Am Soc Clin Investig
EGFR signaling regulates macrophage function, but its role in bacterial infection has not
been investigated. Here, we assessed the role of macrophage EGFR signaling during …
been investigated. Here, we assessed the role of macrophage EGFR signaling during …
Protective role of spermidine in colitis and colon carcinogenesis
Background & Aims Because inflammatory bowel disease is increasing worldwide and can
lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown …
lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown …
Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages
ND Lewis, M Asim, DP Barry, K Singh… - The Journal of …, 2010 - journals.aai.org
Helicobacter pylori infection of the stomach causes peptic ulcer disease and gastric cancer.
Despite eliciting a vigorous immune response, the bacterium persists for the life of the host …
Despite eliciting a vigorous immune response, the bacterium persists for the life of the host …
[HTML][HTML] Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis
CW Barrett, K Singh, AK Motley, MK Lintel… - PloS one, 2013 - journals.plos.org
Selenium (Se) is an essential micronutrient that exerts its functions via selenoproteins. Little
is known about the role of Se in inflammatory bowel disease (IBD). Epidemiological studies …
is known about the role of Se in inflammatory bowel disease (IBD). Epidemiological studies …
Polyamines impair immunity to Helicobacter pylori by inhibiting L-arginine uptake required for nitric oxide production
R Chaturvedi, M Asim, S Hoge, ND Lewis, K Singh… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Helicobacter pylori–induced immune responses fail to eradicate
the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO …
the bacterium. Nitric oxide (NO) can kill H pylori. However, translation of inducible NO …
Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II
ND Lewis, M Asim, DP Barry, T de Sablet… - The Journal of …, 2011 - journals.aai.org
Helicobacter pylori infection persists for the life of the host due to the failure of the immune
response to eradicate the bacterium. Determining how H. pylori escapes the immune …
response to eradicate the bacterium. Determining how H. pylori escapes the immune …
EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis
DM Hardbower, LA Coburn, M Asim, K Singh, JC Sierra… - Oncogene, 2017 - nature.com
Epidermal growth factor receptor (EGFR) signaling is a known mediator of colorectal
carcinogenesis. Studies have focused on the role of EGFR signaling in epithelial cells …
carcinogenesis. Studies have focused on the role of EGFR signaling in epithelial cells …
[HTML][HTML] Dietary arginine regulates severity of experimental colitis and affects the colonic microbiome
There is great interest in safe and effective alternative therapies that could benefit patients
with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with …
with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with …