ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
O De Barrios, B Győrffy, MJ Fernández-Aceñero… - Gut, 2017 - gut.bmj.com
Objective Understand the role of ZEB1 in the tumour initiation and progression beyond
inducing an epithelial-to-mesenchymal transition. Design Expression of the transcription …
inducing an epithelial-to-mesenchymal transition. Design Expression of the transcription …
[HTML][HTML] The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas
Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas
(CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal …
(CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal …