Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
initiation and foster tumour progression. Cancers deficient in MMR frequently show …
Mutations in the RAS‐MAPK, PI (3) K (phosphatidylinositol‐3‐OH kinase) signaling network correlate with poor survival in a population‐based series of colon cancers
Abstract The RAS‐MAPK, PI (3) K signaling pathways form a network that play a central role
in tumorigenesis. The BRAF, KRAS and PI3KCA genes code 3 partners of this network and …
in tumorigenesis. The BRAF, KRAS and PI3KCA genes code 3 partners of this network and …
Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases
L Barault, C Charon-Barra, V Jooste, MF de la Vega… - Cancer research, 2008 - AACR
The CpG island methylator phenotype (CIMP) is a distinct phenotype in colorectal cancer,
associated with specific clinical, pathologic, and molecular features. However, most of the …
associated with specific clinical, pathologic, and molecular features. However, most of the …
Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer
Objective Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking
disease relapse in colorectal cancer (CRC). This approach requires personalised assay …
disease relapse in colorectal cancer (CRC). This approach requires personalised assay …
Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients
The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …
[HTML][HTML] Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements
KB Michels, HR Harris, L Barault - PloS one, 2011 - journals.plos.org
Low birthweight, premature birth, intrauterine growth retardation, and maternal malnutrition
have been related to an increased risk of cardiovascular disease, type 2 diabetes mellitus …
have been related to an increased risk of cardiovascular disease, type 2 diabetes mellitus …
[HTML][HTML] Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer
L Barault, A Amatu, FE Bleeker, C Moutinho… - Annals of oncology, 2015 - Elsevier
ABSTRACT Background O 6-methyl-guanine-methyl-transferase (MGMT) silencing by
promoter methylation may identify cancer patients responding to the alkylating agents …
promoter methylation may identify cancer patients responding to the alkylating agents …
Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer
D Oddo, EM Sennott, L Barault, E Valtorta, S Arena… - Cancer research, 2016 - AACR
Although recent clinical trials of BRAF inhibitor combinations have demonstrated improved
efficacy in BRAF-mutant colorectal cancer, emergence of acquired resistance limits clinical …
efficacy in BRAF-mutant colorectal cancer, emergence of acquired resistance limits clinical …
MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer
F Pietrantonio, D Oddo, A Gloghini, E Valtorta… - Cancer discovery, 2016 - AACR
A patient with metastatic BRAF-mutated colorectal cancer initially responded to combined
EGFR and BRAF inhibition with panitumumab plus vemurafenib. Pre-existing cells with …
EGFR and BRAF inhibition with panitumumab plus vemurafenib. Pre-existing cells with …
Liquid biopsy of cerebrospinal fluid enables selective profiling of glioma molecular subtypes at first clinical presentation
F Orzan, F De Bacco, E Lazzarini, G Crisafulli… - Clinical Cancer …, 2023 - AACR
Purpose: Current glioma diagnostic guidelines call for molecular profiling to stratify patients
into prognostic and treatment subgroups. In case the tumor tissue is inaccessible …
into prognostic and treatment subgroups. In case the tumor tissue is inaccessible …