Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

Helicobacter pylori was definitively identified by culture in 1984 by Robin Warren and Barry
Marshall, 1 and 10 years later this organism was recognized by the International Agency for …

Gastric adenocarcinoma is one of the leading causes of cancer-related death worldwide and
Helicobacter pylori infection is the strongest known risk factor for this disease. Although the …

Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, and strains
that possess the cag secretion system, which translocates the bacterial effector CagA into …

BACKGROUND & AIMS: Helicobacter pylori-induced gastritis predisposes to the
development of gastric cancer. Increased epithelial tight junction permeability and …

BACKGROUND & AIMS: Helicobacter pylori–induced gastric carcinogenesis has been
linked to the microbial oncoprotein cytotoxin-associated gene A (CagA). Spermine oxidase …

Objective Helicobacter pylori strains that express the oncoprotein CagA augment risk for
gastric cancer. However, the precise mechanisms through which cag+ strains heighten …

Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer.
Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early …

Epithelial cell responses to bacterial infection include induction of matrix metalloproteinase
7 (MMP-7). Here, we identify increased MMP-7 expression in the gastric epithelium in …

Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host,
and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in …