The cardiovascular and central nervous system effects in the human of U-62066E: A selective opioid receptor agonist

GH Rimoy, DM Wright, NK Bhaskar… - European journal of clinical …, 1994 - Springer
The cardiovascular and central nervous system effects of the kappa opioid receptor agonist
U-62066E were investigated in ten normal male subjects who received U-62066E or …

Abolition by omeprazole of aspirin induced gastric mucosal injury in man.

TK Daneshmend, AG Stein, NK Bhaskar, CJ Hawkey - Gut, 1990 - gut.bmj.com
This study investigates whether aspirin injury to the human gastric mucosa can be prevented
by profound acid suppression with omeprazole, in a randomised, double blind, crossover …

Mechanism of diuretic action of spiradoline (U‐62066E)‐a kappa opioid receptor agonist in the human.

GH Rimoy, NK Bhaskar, DM Wright… - British journal of …, 1991 - Wiley Online Library
1. The mechanism of the diuretic effect of the kappa opioid receptor agonist spiradoline was
investigated in 10 healthy male subjects in a placebo‐controlled, double‐blind cross‐over …

Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins

CJ Hawkey, RT Kemp, RP Walt, NK Bhaskar, J Davies… - Gastroenterology, 1988 - Elsevier
We investigated the proposition that adaptive cytoprotection (enhanced gastric mucosal
integrity) caused by exposure to 20% ethanol in rats is mediated by endogenous …

Reproducibility of Doppler blood flow velocity waveform measurements: study on variability within and between day and during haemodynamic intervention in normal …

GH Rimoy, NK Bhaskar, PC Rubin - European journal of clinical …, 1991 - Springer
Reproducibility of Doppler blood velocity waveform measurements in external and internal
carotid, middle cerebral, and brachial arteries and ascending aorta was determined in 8 …

Use of microbleeding and an ultrathin endoscope to assess gastric mucosal protection by famotidine

TK Daneshmend, PJ Prichard, NK Bhaskar, PJ Millns… - Gastroenterology, 1989 - Elsevier
We have developed an ultrathin endoscope for repeated endoscopy in unsedated subjects
and used it with assessment of bleeding rates to investigate aspirin-induced gastric mucosal …

Nature and time‐course of piroxicam‐induced injury to human gastric mucosa

IW Fellows, NK Bhaskar… - Alimentary pharmacology …, 1989 - Wiley Online Library
The nature and time‐course of acute piroxicam‐induced gastric mucosal injury was
determined in ten healthy volunteers treated with 10 mg piroxicam twice daily by mouth for …

Gastric mucosal protection with selective inhibition of thromboxane synthesis.

RP Walt, RT Kemp, B Filipowicz, JG Davies… - Gut, 1987 - gut.bmj.com
Because thromboxane synthesis enhances gastric mucosal damage we have investigated
whether the thromboxane synthesis inhibitor dazmegrel might be protective to the mucosa …

Failure of ethamsylate to reduce aspirin‐induced gastric mucosal bleeding in humans.

TK Daneshmend, AG Stein, NK Bhaskar… - British journal of …, 1989 - Wiley Online Library
1. We investigated the effect of the haemostatic agent ethamsylate on aspirin‐induced
gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end …

The influence of food on the pharmacokinetics of 'biphasic'nifedipine at steady state in normal subjects.

GH Rimoy, JR Idle, NK Bhaskar… - British journal of clinical …, 1989 - Wiley Online Library
Previous studies following single dose administration have suggested that the
pharmacokinetics of various nifedipine formulations could be influenced by the timing of …