The oral microbiota in colorectal cancer is distinctive and predictive

…, E Hurley, OR Micheal, F Shanahan, WOT Paul - Gut, 2018 - gut.bmj.com
Background and aims Microbiota alterations are linked with colorectal cancer (CRC) and
notably higher abundance of putative oral bacteria on colonic tumours. However, it is not …

[HTML][HTML] Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults

…, G Ferland, X Fu, SL Booth, TTT Tran, WOT Paul… - The American Journal of …, 2019 - Elsevier
Background Vitamin K has multiple important physiological roles, including blood coagulation
and beneficial effects on myelin integrity in the brain. Some intestinal microbes possess …

[HTML][HTML] Helicobacter pylori motility

WO Paul, MC Lane, S Porwollik - Microbes and infection, 2000 - Elsevier
Motility is essential for Helicobacter pylori colonization. This review discusses the
biochemistry, genetics and genomics of the H. pylori flagellum, and compares these features …

Prevalence of malnutrition using harmonized definitions in older adults from different settings–A MaNuEL study

…, M O'Keeffe, M Kelly, E O'Herlihy, PW O'Toole… - Clinical nutrition, 2019 - Elsevier
Background & aims Malnutrition is widespread among older people and related to poor
outcome. Reported prevalences vary widely, also because of different diagnostic criteria used. …

Randomised study of endoscopic biliary endoprosthesis versus duct clearance for bileduct stones in high-risk patients

KB Chopra, RA Peters, PA O'Toole, SGJ Williams… - The Lancet, 1996 - thelancet.com
Background The value of an endoprosthesis for long-term management of bileduct stones
has not been formally established. The main theoretical advantage of endoprosthesis …

[HTML][HTML] Toward an improved definition of a healthy microbiome for healthy aging

TS Ghosh, F Shanahan, PW O'Toole - Nature Aging, 2022 - nature.com
The gut microbiome is a modifier of disease risk because it interacts with nutrition, metabolism,
immunity and infection. Aging-related health loss has been correlated with transition to …

[HTML][HTML] Whole blueberry and isolated polyphenol-rich fractions modulate specific gut microbes in an in vitro colon model and in a pilot study in human consumers

…, MC Neto, A Howell, A Thalacker-Mercer, PW O'Toole - Nutrients, 2020 - mdpi.com
Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic
content of BB by fermentative bacteria in the large intestine may be a necessary step for …

Non‐motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production

PW O'Toole, M Kostrzynska, TJ Trust - Molecular microbiology, 1994 - Wiley Online Library
Flagellar hooks were purified from Helicobacter pylori and Helicobacter mustelae. The 70 ×
16nm H. pylori hook was composed of FIgE subunits of 78kDa, while the 72 × 16nm H. …

[HTML][HTML] Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants

…, IB Jeffery, CA Ryan, RP Ross, C Stanton, PW O'Toole - Microbiome, 2016 - Springer
Background Alterations in intestinal microbiota have been correlated with a growing number
of diseases. Investigating the faecal microbiota is widely used as a non-invasive and …

Microbiome alterations in IBS

IB Jeffery, E O'Herlihy, F Shanahan, PW O'Toole - Gut, 2020 - gut.bmj.com
We commend the editors of Gut for publishing the article by Hugerth et al 1 given that negative
results are conspicuously missing from the microbiome literature. The paper reports that …