The composition of the intestinal microbiota varies among individuals and throughout
development, and is dependent on host and environmental factors. However, although the …

Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and
psoriasis are triggered by hitherto unknown environmental factors that function on the …

Here we describe the LifeTime Initiative, which aims to track, understand and target human
cells during the onset and progression of complex diseases, and to analyse their response …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …

Genome sequencing projects are discovering millions of genetic variants in humans, and
interpretation of their functional effects is essential for understanding the genetic basis of …

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine,. Patients with leukaemia can be identified using machine …

Malnutrition affects up to one billion people in the world and is a major cause of mortality,. In
many cases, malnutrition is associated with diarrhoea and intestinal inflammation, further …

Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has
exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly …