Objective To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma
(EAC) and its precursor Barrett’s oesophagus (BE). Design We performed genome-…

Colorectal cancer (CRC) results from the accumulation of gene mutations and epigenetic
alterations in colon epithelial cells, which promotes CRC formation through deregulating …

Background: Barrett's esophagus (BE) is a preneoplastic condition in which normal esophageal
squamous epithelium (SQ) is replaced by specialized intestinal metaplasia. It is the …

Importance Many psychiatric outcomes share a common etiologic pathway reflecting
behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent genome-…

Herpesviruses are highly prevalent in the human population, and frequent reactivations
occur throughout life. Despite antiviral drugs against herpetic infections, the increasing …

Theorists have noted that social rejection, uncertainty, error evaluation, regret, and cognitive
dissonance all activate the same neural substrate as physical pain; specifically, the anterior …

Crohn’s disease (CD) is a chronic inflammatory disease (IBD) that can affect the entire
gastrointestinal tract in a non-continuous mode. CD is generally diagnosed most commonly …

Objectives To explore family-centred care practices in Italian neonatal intensive care units
and describe areas for improvement. Methods A cross-sectional, multicentre, survey was …

Two clinically approved anticancer drugs targeting BRAF in melanoma patients – dabrafenib
(DAB) and vemurafenib (VEM) – have been successfully encapsulated into nanomicelles …

Glioblastomas (GBs) are among the most common tumors with high malignancy and
invasiveness of the central nervous system. Several alterations in protein kinase and ion channel …