Colorectal cancer is a significant cause of morbidity and mortality in Western populations.
This cancer develops as a result of the pathologic transformation of normal colonic …

Background Colon cancers with high-frequency microsatellite instability have clinical and
pathological features that distinguish them from microsatellite-stable tumors. We …

Background Colorectal cancer can arise through two distinct mutational pathways:
microsatellite instability or chromosomal instability. We tested the hypothesis that colorectal …

Objective: To measure sexual function and quality of life (QOL) after rectal cancer treatment.
Summary Background Data: Previous studies on sexual function after rectal cancer …

BACKGROUND: Pancreatic cancer is a rapidly fatal disease with very few 5-year survivors
even after aggressive surgical treatment. Our objective was to determine the actual 5-year …

The MutY human homologue (MYH) gene encodes a member of the base excision repair
pathway that is involved in repairing oxidative damage to DNA. Two germline MYH gene …

Some colorectal tumors with wild-type adenomatous polyposis coli gene have activating
mutations in β-catenin (encoded by CTNNB1) that result in decreased phosphorylation by …

Colorectal cancer is common in the Western world;~ 5% of individuals diagnosed with
colorectal cancer have an identifiable inherited genetic predisposition to this malignancy …

Inactivation of deoxyribonucleic acid (DNA) mismatch repair genes, most commonly human
mutL homologue 1 (hMLH1) or human mutS homologue 2 (hMSH2), is a recently described …

Transforming growth factor-β (TGF-β) and Wnt ligands function in numerous developmental
processes, and alterations of both signaling pathways are associated with common …