The Wnt/β‐catenin signalling and autophagy pathways each play important roles during
development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β …

As tumours are known to acidify their microenvironment and fluctuations in lumenal pH have
been reported in a number of colonic disease conditions, we investigated whether loss of …

We compared the timing of reproduction by insectivorous bats in 1990, a wet year, with
previously published data to test the prediction that reproduction is delayed by excess …

With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central role
in regulating NF-κB signalling, it is perhaps not surprising that there have been an …

Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer
from normal tissue. However, a major challenge remains in identifying tractable molecular …

Quantitative prediction of human pharmacokinetics is critical in assessing the viability of
drug candidates and in determining first‐in‐human dosing. Numerous prediction …

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated
levels of prostaglandin E 2 (PGE 2), promoting many hallmarks of cancer. Importantly, PGE 2 …

Despite recent advances in understanding colorectal tumour biology, there is still a need to
improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of …

We investigated the expression of insulin-like growth factor binding protein 3 (IGFBP-3) in
normal human colonic epithelium and whether IGFBP-3 is involved in the induction of …

Objective Colorectal cancer remains the fourth most common cause of cancer-related
mortality worldwide. Here we investigate the role of nuclear factor-κB (NF-κB) co-factor B-cell …