Over two decades of research on venom peptides derived from cone snails (“conopeptides
or conotoxins”) has led to several compounds that have reached human clinical trials, most …

Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta
cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker …

Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality
worldwide. Current systemic therapies result only in modest benefits and new therapeutic …

Objective Transient receptor potential ankyrin-1 (TRPA1) and transient receptor potential
vanilloid-1 (TRPV1) are calcium (Ca2+)-permeable ion channels mostly known as pain …

Atrophic vaginitis represents a major barrier to compliance with aromatase inhibitor (AI)
therapy in breast cancer (BC) survivors. While local estrogen therapy is effective for …

Transforming the neuroactive toxins of cone snails into small‐size compounds poses a
challenge due to the presence of multiple disulfide bridges. Herein we describe our …

Disulfide-rich peptides represent a megadiverse group of natural products with very
promising therapeutic potential. To accelerate their functional characterization, high …

Objective To investigate sex and racial/ethnic differences in overweight and obesity in
college students. Participants: A nationally representative sample of 319,342 US college …

Despite the therapeutic promise of disulfide-rich, peptidic natural products, their discovery
and structure/function studies have been hampered by inefficient oxidative folding methods …