Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4)
WT Choi, S Duggineni, Y Xu, Z Huang… - Journal of medicinal …, 2012 - ACS Publications
RECEPTORS Chemokines are small 70 amino acid long soluble proteins that chemoattract
a variety of mononuclear cell types to sites of inflammation or secondary lymphoid organs by …
a variety of mononuclear cell types to sites of inflammation or secondary lymphoid organs by …
Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis
WT Choi, Y Yang, Y Xu, J An - Current topics in medicinal …, 2014 - ingentaconnect.com
The chemokine receptor CXCR4 is required for the entry of human immunodeficiency virus
type 1 (HIV-1) into target cells and for the development and dissemination of various types of …
type 1 (HIV-1) into target cells and for the development and dissemination of various types of …
Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases
WT Choi, J An - Experimental Biology and Medicine, 2011 - journals.sagepub.com
Chemokines and their receptors are implicated in a wide range of human diseases,
including acquired immune deficiency syndrome (AIDS). The entry of human …
including acquired immune deficiency syndrome (AIDS). The entry of human …
Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1α on CXCR4 transmembrane helical domains
S Tian, WT Choi, D Liu, J Pesavento, Y Wang… - Journal of …, 2005 - Am Soc Microbiol
The entry of human immunodeficiency virus type 1 (HIV-1) into the cell is initiated by the
interaction of the viral surface envelope protein with two cell surface components of the …
interaction of the viral surface envelope protein with two cell surface components of the …
[HTML][HTML] Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal carcinoma: a multicenter clinicopathologic study
WT Choi, M Yozu, GC Miller, AR Shih… - Modern Pathology, 2020 - Elsevier
Several types of nonconventional dysplasia have been recently described in inflammatory
bowel disease (IBD). However, strict morphologic criteria are lacking, and their …
bowel disease (IBD). However, strict morphologic criteria are lacking, and their …
Association of aneuploidy and flat dysplasia with development of high-grade dysplasia or colorectal cancer in patients with inflammatory bowel disease
JH Tsai, PS Rabinovitch, D Huang, T Small, AN Mattis… - Gastroenterology, 2017 - Elsevier
There is controversy over how to best manage patients with inflammatory bowel disease and
flat low-grade dysplasia (fLGD) in the colon. We performed a retrospective analysis of …
flat low-grade dysplasia (fLGD) in the colon. We performed a retrospective analysis of …
Non‐conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia
H Lee, PS Rabinovitch, AN Mattis, GY Lauwers… - …, 2021 - Wiley Online Library
Aims Several different non‐conventional morphological patterns of epithelial dysplasia have
been recently described in inflammatory bowel disease (IBD), but there is limited information …
been recently described in inflammatory bowel disease (IBD), but there is limited information …
Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases
WT Choi, I Brown, T Ushiku, M Yozu, N Setia… - …, 2018 - Wiley Online Library
Aims There is limited information regarding the clinicopathological and
immunohistochemical characteristics of gastric pyloric gland adenomas (PGA s). Methods …
immunohistochemical characteristics of gastric pyloric gland adenomas (PGA s). Methods …
Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 …
The chemokine receptor CXCR4 plays an important role as the receptor for the normal
physiological function of stromal cell-derived factor 1α (SDF-1α) and the coreceptor for the …
physiological function of stromal cell-derived factor 1α (SDF-1α) and the coreceptor for the …
Hypermucinous, goblet cell-deficient and crypt cell dysplasias in inflammatory bowel disease are often associated with flat/invisible endoscopic appearance and …
Abstract Background and Aims Several different types of non-conventional dysplasia have
been recently described in inflammatory bowel disease [IBD]. Hypermucinous, goblet cell …
been recently described in inflammatory bowel disease [IBD]. Hypermucinous, goblet cell …