Background & Aims Obesity defined by body mass index (BMI) significantly increases the
risk of hepatocellular carcinoma (HCC). In contrast, not only obesity but also underweight is …

Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the …

Objective Metabolic reprogramming of tumour cells that allows for adaptation to their local
environment is a hallmark of cancer. Interestingly, obesity-driven and non-alcoholic …

Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins
(SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In …

Oxidative stress plays a critical role in liver tissue damage and in hepatocellular carcinoma
(HCC) initiation and progression. However, the mechanisms that regulate autophagy and …

Genetic mutations in pancreatic ductal adenocarcinoma (PDAC) with critical roles have
been well examined. The recent discovery of alterations in genes encoding histone …

Cancer-associated fibroblasts (CAFs) promote tumor malignancy, but the precise
transcriptional mechanisms regulating the acquisition of the CAF phenotype are not well …

Chronic inflammation is thought to promote tumorigenesis and metastasis by several
mechanisms, such as affecting tumor cells directly, establishing a tumor-supporting …

BACKGROUND & AIMS: Although colorectal cancer (CRC) progression has been
associated with alterations in KRAS and RAS signaling, not all CRC cells have KRAS gene …

BACKGROUND & AIMS: Some clinical findings have suggested that systemic metabolic
disorders accelerate in vivo tumor progression. Deregulation of the phosphatidylinositol 3 …