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Interface between the intestinal environment and the nervous system
  1. O Lundgren
  1. Correspondence to:
    Professor O Lundgren
    Department of Physiology, Sahlgrenska Academy, Göteborg University, Box 432, S-405 30 Göteborg, Sweden; ove.lundgrenfysiologi.gu.se

Abstract

Possible mechanisms by which the intestinal contents may influence afferent nerve fibres in the lamina propria of the intestinal mucosa are discussed in this brief review. After addressing intestinal epithelial permeability, endocrine and brush cells are discussed, as well as enterocytes, as sensors for luminal microbes.

  • intestinal environment
  • nervous system
  • visceral afferent mechanism
  • CCK, cholecystokinin
  • EC, enterochromaffin
  • cAMP, cyclic adenosine monophosphate
  • 5-HT, 5-hydroxytryptamine
  • CNS, central nervous system
  • NO, nitric oxide
  • NOS1, nitric oxide synthase 1

https://doi.org/10.1136/gut.2003.033449

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      Summary
      M Costa H Glise H Graffner
      Gut 2004; 53 ii22-ii25 Published Online First: 11 Feb 2004. doi: 10.1136/gut.2003.033472