Gut,
a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews
Impact Factor: 31.795
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Inflammatory bowel disease:
Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study7 March 2023
Hepatology:
Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis7 February 2023
Gut microbiota:
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice5 January 2023
Most Read Articles
Guidelines:
British Society of Gastroenterology guidelines on the management of functional dyspepsia11 August 2022
Guidelines:
Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report11 August 2022
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Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification
Conclusion: Impaired epithelial RAC1 function causes cell overcrowding and epithelial leakage thus inducing chronic intestinal inflammation. Epithelial RAC1 emerges as key regulator of cytoskeletal dynamics, cell mechanics and intestinal cell shedding. Modulation of RAC1 might be exploited for restoration of epithelial integrity in the gut of patients with IBD.
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