Gut,
a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews
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Latest Articles
Letter:
Primary prophylaxis in patients with high risk oesophageal varices to prevent oesophageal variceal bleeding (OVB)--The CAVARLY is stronger together!!29 November 2024
GI cancer:
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF228 November 2024
Recent advances in clinical practice:
Recent advances in incretin-based therapy for MASLD: from single to dual or triple incretin receptor agonists26 November 2024
Letter:
Sphincterotomy with FCSEMS (SPHINX): a monumental answer or the beginning of new mysteries?26 November 2024
Most Read Articles
Guidelines:
Endoscopy in patients on antiplatelet or anticoagulant therapy: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guideline update29 January 2024
Recent advances in clinical practice:
Updates to the modern diagnosis of GERD: Lyon consensus 2.05 January 2024
Recent advances in clinical practice:
MASLD: a systemic metabolic disorder with cardiovascular and malignant complications7 March 2024
Gut microbiota:
Blue poo: impact of gut transit time on the gut microbiome using a novel marker29 January 2024
Guideline:
British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy7 March 2024
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Podcasts
Featured Video
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
Conclusion: Our transcriptomic characterisation of SLGN sheds light into the programmes regulating KC activation. Furthermore, in addition to its previously described effect on established HBV infection and adaptive immunity, we show that SLGN impairs HBV entry. Altogether, SLGN may contribute through KCs to remodelling the intrahepatic immune microenvironment and may thus represent an important component of future combinations to cure HBV infection.
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