a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews

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Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn’s disease

Conclusion Distinct gut bacterial IgG2-coating was demonstrated in patients with severe CD and during disease flares. Co-occurrence of non-coated pathobionts with IgG2-coated bacteria points to an uncontrolled inflammatory condition in severe CD mediated via escape from antibody coating by two gut pathobionts.

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