Gut,
a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews
Impact Factor: 31.795
Citescore: 40.1
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Recent advances in basic science:
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease5 May 2023
Gut microbiota:
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism4 April 2023
Inflammatory bowel disease:
Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study7 March 2023
Most Read Articles
Guidelines:
British Society of Gastroenterology guidelines on the management of functional dyspepsia11 August 2022
Guidelines:
Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report11 August 2022
Inflammatory bowel disease:
Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study9 January 2023
Latest Articles
Recent advances in basic science:
Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours31 May 2023
Letter:
Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination31 May 2023
Inflammatory bowel disease:
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases26 May 2023
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Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
Our study identified a new mechanism linking Trp metabolism to intestinal inflammation and IBD. Bringing back XANA and KYNA has protective effects involving AhR and the rewiring of the energy metabolism in intestinal epithelial cells and CD4+ T cells. This study paves the way for new therapeutic strategies aiming at pharmacologically correcting its alterations in IBD by manipulating the endogenous metabolic pathway with AADAT.
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