a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research and reviews

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Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification

Conclusion: Impaired epithelial RAC1 function causes cell overcrowding and epithelial leakage thus inducing chronic intestinal inflammation. Epithelial RAC1 emerges as key regulator of cytoskeletal dynamics, cell mechanics and intestinal cell shedding. Modulation of RAC1 might be exploited for restoration of epithelial integrity in the gut of patients with IBD.

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