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Gut is a Plan S compliant Transformative Journal.

Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles by leading authorities describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future.

Gut is an official journal of the British Society of Gastroenterology and has two companion journals, Frontline Gastroenterology and BMJ Open Gastroenterology.

Editor-in-Chief: Professor Emad El-Omar, University of New South Wales, Sydney, Australia
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COVID-19: a message from BMJ >>

Guidance from BSG: COVID-19 and Endoscopy

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Gut

COVID-19 Gastroenterology Collection

 

Our new online collection highlights all research relating to the COVID-19 pandemic published by Gut, Frontline Gastroenterology and BMJ Open Gastroenterology. It is updated regularly as new articles are published.

 

All content is free to read and features original research, commentaries, letters and editorials from all three journals published with the British Society of Gastroenterology (BSG)

 

Visit the full BMJ Coronavirus resource collection for all the latest content from across our portfolio

 

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Visual Abstracts provide summaries of the latest research in a single, visual format

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Featured Video

Characterisation of pancreatic ductal adenocarcinoma with microsatellite instability

To cite: Luchini C, Brosens LAA, Wood LD et al. Gut 2021;70:148-156.

Read the full article here: link
Objective: ecently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) have gained considerable interest due to the success of immunotherapy in this molecular setting. Here, we aim to clarify clinical-pathological and/or molecular features of this tumour subgroup through a systematic review coupled with a comparative analysis with existing databases, also providing indications for a correct approach to the clinical identification of MSI/dMMR pancreatic ductal adenocarcinoma (PDAC).

Conclusions: PDAC showing typical medullary or mucinous/colloid histology should be routinely examined for MSI/dMMR status using specific tests (immunohistochemistry, followed by MSI-PCR in cases with doubtful results). Next-generation sequencing (NGS) should be adopted either where there is limited tissue or as part of NGS tumour profiling in the context of precision oncology, acknowledging that conventional histology of PDAC may rarely harbour MSI/dMMR.

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