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Clinical, microbiological, and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders
  1. W. R. Brown,
  2. D. Butterfield,
  3. D. Savage,
  4. T. Tada


    Seven patients with gastrointestinal disorders and deficiencies of serum and secretory immunoglobulins were evaluated clinically, microbiologically, and immunologically. Five patients had generalized deficiencies of immunoglobulins; two were selectively deficient. Diarrhoea and malabsorption in six of the seven patients were at least partially explained. Four of the five patients with generalized hypogammaglobulinaemia had intestinal infestation with Giardia lamblia; in three of the five, excessive numbers of anaerobic bacteria were cultured from small bowel fluids. Despite much variability in relative severity of patients' respiratory and gastrointestinal tract symptoms, deficiencies of mucosal immunocytes and immunoglobulins in nasopharyngeal and gastrointestinal tract tissues and secretions were similar. Except for one selectively IgA-deficient patient, all patients were deficient in IgE. The study characterizes in greater detail than heretofore the gastrointestinal disorders associated with immunoglobulin deficiency states.

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    • 1 This investigation was supported by Denver Veterans Administration Hospital training grant in gastroenterology TR 110; by a grant (FR-51) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health; Denver Veterans Administration Hospital; NIH special fellowship 5 FO3 AM 38896-02; and USPHS research grant AI-08254-03.